We investigate the ancient arms race between "selfish genes" and eukaryotes. Our goal is to gain novel mechanistic insights into diverse gene regulatory processes and uncover principles of transposon-host co-evolution by studying the genetics, genomics and biochemistry of small RNA-guided transposon silencing systems in the animal germline.


Publications

Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery (2022)
Andreev VI, Yu C, Wang J, Schnabl J, Tirian L, Gehre M, Handler D, Duchek P, Novatchkova M, Baumgartner L, Meixner K, Sienski G, Patel DJ, Brennecke J.
Nature Structural & Molecular Biology. 29 (2), 130-142

A heterochromatin-specific RNA export pathway facilitates piRNA production (2019)
ElMaghraby MF, Andersen PR, Puehringer F, Meixner K, Lendl T, Tirian L, Brennecke J.
Cell. 178 (4), 964-979

A heterochromatin-dependent transcription machinery drives piRNA expression (2017)
Andersen PR, Tirian L, Vunjak M, Brennecke J.
Nature 549 (7670), 54-59


Phone
+43 1 79044 4508


E-mail:
julius.brennecke@imba.oeaw.ac.at