Our group is interested in unraveling the molecular determinants that allow the establishment of a potent RNA interference response in which small RNAs are used to silence the expression of genes. We address these questions by combining various structural biology techniques with quantitative biochemistry.


Publications

Podvalnaya N.#, Bronkhorst A.W.#, Lichtenberger R., Hellmann S., Nischwitz E.,  Falk T., Karaulanov E., Butter F., Falk S.*, Ketting R.* (2023) piRNA processing by a trimeric Schlafen-domain nuclease. Nature, doi:10.1038/s41586-023-06588-2.  PMID: 37758951 # equally contributed; *Shared correspondence

Perez-Borrajero C., Podvalnaya N.#, Holleis K.#, Lichtenberger R., Basquin J., Hennig J.*, Ketting R.F.*, Falk S.* (2021) Structural basis of PETISCO complex assembly during piRNA biogenesis in C. elegans. Genes Dev. PMID: 34413138 # equally contributed; *Shared correspondence

Schuller, J.M.#, Falk, S.#, Fromm, L., Hurt, E. and Conti, E. (2018). Structure of the nuclear exosome captured on a maturing pre-ribosome.  Science Apr 13; 360, 219-222 PMID: 29519915 # equally contributed


Phone
+43 1 4277 74360


E-mail:
sebastian.falk@univie.ac.at