We aim to unravel novel principles and pathways underlying signal-perception, -transduction and cellular regulation in the model organism Escherichia coli.

We study a regulatory network consisting of trans-envelope and ribonucleoprotein complexes as well as a phosphotransferase system, which integrates extra-cytoplasmic signals and information about the metabolic state of the cell to achieve cell envelope homeostasis.


Publications

Schilder A, Görke B. Role of the 5' end phosphorylation state for small RNA stability and target RNA regulation in bacteria. (2023) Nucleic Acids Res. 51(10):5125-5143. doi: 10.1093/nar/gkad226.

Islam MS, Hardwick SW, Quell L, Durica-Mitic S, Chirgadze DY, Görke B, Luisi BF. (2023) Structure of a bacterial RNP complex central to the control of cell envelope biogenesis.
EMBO J. 42(2):e112574. doi: 10.15252/embj.2022112574.

Khan MA, Durica-Mitic S, Göpel Y, Heermann R, Görke B. (2020) Small RNA-binding protein RapZ mediates cell envelope precursor sensing and signaling in Escherichia coli. EMBO J. 39(6):e103848. doi: 10.15252/embj.2019103848.


Phone
+43 1 4277 54603


E-mail:
boris.goerke@univie.ac.at


Address:
Department of Microbiology, Immunobiology and Genetics
Max Perutz Labs
University of Vienna
Dr. Bohrgasse 9, lab 4110
1030 Vienna
Austria