Karagöz lab is interested in understanding how cells sense and respond to perturbations to protein folding homeostasis, termed as proteotoxic stress. Combining systems-levels methods with biochemistry and structural biology, we aim to dissect the posttranscriptional and translational mechanisms involved in adaptation to cellular stress. 


Publications

Kettel P*, Marosits L*, Spinetti E, Rechberger M, Radler P, Niedermoser I, Fischer I, Versteeg GA, Loose M, Covino R, Karagöz GE. (2023). “Stress-induced clustering of the UPR sensor IRE1α is driven by disordered regions within its ER luminal domain”. bioRxiv, doi: 10.1101/2023.03.30.534746 *These authors contributed equally.

Anisimova AS, Karagöz GE. (2023) “Optimized infrared photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation (IR-PAR-CLIP) protocol identifies novel IGF2BP3-interacting RNAs in colon cancer cells”. RNA, accepted for publication.

Picchianti L*, Sánchez de Medina Hernández V*, Zhan N*, Irwin NAT, Stephani M ,  Hornegger M ,  Beveridge R,  Sawa-Makarska J , Lendl  T , Grujic N, Martens S, Richards TA, Clausen T, Ramundo S, Karagöz GE#, Dagdas Y#. (2022) “Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and C53-mediated autophagy” EMBO J, 10.15252/embj.2022112053. #Corresponding authors. *Equal contributions.


Phone
+43 1 4277 61635



Address:
Max Perutz Labs

Dr. Bohrgasse 9,
1030 Vienna,

Austria