My Laboratory studies RNA processing in mammalian cells with links to metabolism, cellular homeostasis and disease. Within RNA@core we will deal with the biochemistry and biology of enzymes that modify RNA termini. We will dissect the function of the subunits that compose the tRNA ligase complex and the dynamics – synthesis and degradation – of 2’, 3’ cyclic phosphates. We embrace curiosity, expertise, intuition and networking, and good doses of serendipity.


Publications

Thioredoxin regulates the redox state and the activity of the human tRNA ligase complex.
Jaksch D, Irnstorfer J, Kalman PF, Martinez J.
RNA. 2023 Aug 30:rna.079732.123.
doi: 10.1261/rna.079732.123. Online ahead of print.
PMID: 37648453 Free article.

The oxidoreductase PYROXD1 uses NAD(P)+ as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response.
Asanović I, Strandback E, Kroupova A, Pasajlic D, Meinhart A, Tsung-Pin P, Djokovic N, Anrather D, Schuetz T, Suskiewicz MJ, Sillamaa S, Köcher T, Beveridge R, Nikolic K, Schleiffer A, Jinek M, Hartl M, Clausen T, Penninger J, Macheroux P, Weitzer S, Martinez J.
Mol Cell. 2021 Jun 17;81(12):2520-2532.e16.
doi: 10.1016/j.molcel.2021.04.007. Epub 2021 Apr 29.
PMID: 33930333 Free article.

ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity.
Pinto PH, Kroupova A, Schleiffer A, Mechtler K, Jinek M, Weitzer S, Martinez J.
Science. 2020 Jul 31;369(6503):524-530.
doi: 10.1126/science.aba9763.
PMID: 32732418



Phone
+43 1 4277 61803


E-mail:
Javier.martinez@meduniwien.ac.at


Address:
Center for Medical Biochemistry
Max Perutz Labs
Medical University of Vienna
Dr. Bohr-Gasse 9/2
1030 Vienna
Austria