Our research is centred on investigating how Escherichia coli can reprogram its translational landscape under challenging conditions. We are particularly intrigued by the ribosome, a sophisticated molecular assembly made up of RNA and proteins, and our recent investigations have unveiled reversible ribosome heterogeneity as an extra layer of regulation in response to environmental stress.


Publications

Vesper, O., Amitai, S., Belitsky, M., Byrgazov, K., Kaberdina, A.-C., Engelberg-Kulka, H. and Moll, I. (2011) Selective Translation of Leaderless mRNAs by Specialized Ribosomes Generated by MazF in Escherichia coli. Cell, 147, 147-157.

Sauert, M., Wolfinger, M. T., Vesper O., Müller, C., Byrgazov, K., and Moll, I. (2016) The MazF-regulon: A toolbox for the post-transcriptional stress response in Escherichia coli. Nucleic Acids Res., 44(14):6660-75, doi: 10.1093/nar/gkw115.

Temmel, H., Müller, C., Sauert, M., Vesper, O., Reiss, A., Popow, J., Martinez, J., and Moll, I. (2017) The RNA ligase RtcB reverses MazF-induced ribosome heterogeneity in Escherichia coli. Nucl. Acids Res. 45 (8): 4708-4721; doi: 10.1093 /nar/gkw1018.


Phone
+43 1 4277 54606


Mobile
+43 664 817 5805


E-mail:
Isabella.moll@univie.ac.at


Address:

MAX PERUTZ LABS
DEPARTMENT OF MICROBIOLOGY, 
 IMMUNOBIOLOGY AND GENETICS 
UNIVERSITY OF VIENNA

Vienna BioCenter (VBC)
Dr.-Bohr-Gasse 9

1030 Vienna
Austria