How do molecular machines prepare messenger RNA for gene expression? In our group, we apply structural and functional methods to reveal the molecular basis of human mRNA biogenesis and the coordination between maturation events. Our goal is to understand how an mRNA is made.


Publications

B. Pacheco-Fiallos, M. K. Vorländer, D. Riabov-Bassat, L. Fin, F. Ayala, F. J. O’Reilly, J. Rappsilber, and C. Plaschka. mRNA recognition and packaging by the human transcription-export complex. Nature (2023) 616, 828–835


T. Pühringer, U. Hohmann, L. Fin, B. Pacheco-Fiallos, U. Schellhaas, J. Brennecke, C. Plaschka. Structure of the human core transcription-export complex reveals a hub for multivalent interactions. eLife (2020) 9:e61503.

C. Plaschka, P.-C. Lin, C. Charenton, K. Nagai#. Prespliceosome structure provides insight into spliceosome assembly and regulation. Nature (2018) 558, 419-422.



Phone
+43 1 79730 3451



E-mail:
clemens.plaschka@imp.ac.at


Address:
IMP
Research Institute of Molecular Pathology

Campus Vienna Biocenter
1
1030 Vienna
Austria